a) Catalytic hydrogenation reaction

Catalytic hydrogenation refers to the addition reaction of a reducing agent or hydrogen molecules to unsaturated compounds under the action of a catalyst, including the catalytic hydrogenation of alkenes, alkynes, aromatic rings, nitrogen-containing compounds, etc., which has a wide reduction range and high reaction activity, Good selectivity, fast speed, convenient post-processing, mild reaction conditions, convenient operation, economical application, so it has a wide range of applications in drug synthesis.

b) Ultra-low temperature reaction

Ultra-low temperature reaction can effectively improve the process yield and product purity. This technology has been applied in many fields and has a broad development prospect. SunwayPharm has used ultra-low temperature reaction (-80℃) technology to synthesize new molecular building blocks with diversified structures, which can enrich customers' personalized choices.

c) Fluorination

Organic fluorination technology is very important in the pharmaceutical industry. Among the 38 small molecule drugs approved by the U.S. FDA in 2018, 18 are fluorine-containing drugs. The introduction of fluorine atoms or fluorine-containing groups into drug molecules can change the permeability and metabolic stability of drug molecules, adjust their pKa and fat solubility, and affect the absorption and distribution of drug molecules and their interaction with biological targets. This has gradually become a common method for drug screening. SunwayPharm has widely applied fluorination reaction technology to the synthesis of key intermediates of related drugs and small molecules.

d) Chiral asymmetric synthesis

Asymmetric synthesis is "an organic reaction in which the achiral unit in the substrate molecule is converted into a chiral unit by the way that the reactants generate stereoisomeric products in unequal amounts". Chiral drugs account for more than 60% of the chemical drugs commonly used in the world today. Therefore, asymmetric synthesis currently plays a very important role in drug synthesis.

e) Enzyme Catalysis

SunwayPharm utilizes enzyme catalysis technology to produce high value-added key pharmaceutical intermediates, simplifying the reaction process, improving product utilization, and reducing equipment energy consumption. This technology owns a very broad prospect for the development of medicine, especially in the synthesis of key pharmaceutical intermediates.

f) Continuous reaction

SunwayPharm uses continuous reaction technology to improve purity and perform technical reaction connection efficiently, simplifying the process while ensuring the stability and safety of the operation. This technology has been applied in laboratories and customized synthesis to provide customers with efficient and quality product services.